科学研究

职业危害识别与控制湖北省重点实验室近年科学研究成果

1、近年承担的主要科研项目

1.  老年人轻度认知功能障碍社区全覆盖式健康管理与防控模式的构建,国家自然科学基金(71774127),立项时间:2018

2.  基于5-HT受体亚型乙酰化修饰探讨阿尔茨海默病精神行为症状(BPSD)的发生机制与防治新途径,国家自然科学基金(81771488),立项时间:2018

3.  自噬抑制NOD信号负反馈调节副猪嗜血杆菌的致炎反应,国家自然科学基金(3170130210),立项时间:2018

4.  环状RNA-mm9-circ-008009募集miRNA-471-3p在糖尿病心肌细胞焦亡中的作用,国家自然科学基金(81770377),立项时间:2018

5.  逆转录病毒蛋白酶抑制剂Lopinavir/r通过lncTUG1诱导血管内皮细胞老化的分子机制研究,国家自然科学基金(81700446),立项时间:2018

6.  IFT20/Snapin/SPAG6蛋白复合体通过荷载转运蛋白和自噬作用调节精子发生,国家自然科学基金81671514),立项时间:2017

7.  Wnt5a, HIV外周神经病的关键通路及治疗靶点,国家自然科学基金(31671092),立项时间:2017

8.  心房钠尿肽阻抑心室肌细胞晚钠电流与胞内钙离子之间正反馈的机制研究,国家自然科学基金(81670302),立项时间:2017

9.  妊娠期糖尿病遗传基因易感性与同型半胱氨酸的交互作用及其机制研究,国家自然科学基金81703239),立项时间:2017

10.肿瘤源性Reg3驯导树突状细胞促进胰腺癌免疫逃逸的作用及机制研究,国家自然科学基金(81602108),立项时间:2017

11.增能理论视角下城市失独父母的生存压力与社会支撑研究,国家社会科学基金17BSH119),立项时间:2017

12.组蛋白去乙酰化酶6调控纤毛自噬在炭黑颗粒致气道重构中的作用机制,国家自然科学基金81502792),立项时间:2016

13.RC/BTB2对纤毛形成及精子发生的作用,国家自然科学基金81571428),立项时间:2016

14.应用第二代测序和生物信息学技术研究肠道微生物群系与大肠癌发病之间的关系,国家自然科学基金(81573239),立项时间:2016

15.ICAM5RNA结合蛋白FMRP的动态关联机制及其对脆性X综合征树突棘成熟的影响,国家自然科学基金(81571095),立项时间:2016

16.农村留守儿童性侵犯风险特征与干预对策研究,国家社会科学基金15BSH057),立项时间:2016

17.吸毒人群社会融合的困境及促进对策研究,国家社会科学基金(14BSH089),立项时间:2015

18.S-SOX5对运动纤毛基因的转录调节及对精子鞭毛结构和功能的影响,国家自然科学基金(81300536),立项时间:2014

19.ROS/MAPK调控TR4DEHP诱导小鼠生精细胞凋亡中的作用,国家自然科学基金(81302401),立项时间:2014

20.TrkB激动剂7,8-dihydroxyflavone对脆性X综合征突触可塑和学习记忆的影响及机制,国家自然科学基金(31271199),立项时间:2013

21.SIRT2调节心肌细胞微管稳定性与糖尿病心肌病关系研究,国家自然科学基金(81102437),立项时间:2012

22.托特罗定-一种心肌细胞持续性钠电流高效阻断剂的研究,国家自然科学基金(81072637),立项时间:2011

23.心室肌细胞持续性钠电流与胞内钙离子之间的正反馈调节机制,国家自然科学基金(30870912),立项时间:2009

24.cAMP-蛋白激酶A系统对心室肌细胞瞬时钠电流和持续性钠电流之间互变现象的调制作用,国家自然科学基金(30670764),立项时间:2007

25.MEIG1单个氨基酸突变对其结合PACRG及精子鞭毛形成的影响,湖北省科技厅杰青基金(2018CFA040),立项时间:2018

26.宋世震等,职业接触丙酮的生物限值,国家卫生部(20130206),立项时间:2013

27.宋世震等,尿中丙酮的测定方法,国家卫生部(20130207),立项时间:2013

28.梅勇等,全国重点地区环境与健康专项调查技术文件编写与技术督导,国家环境保护部(201111011101EHH201125),立项时间:2011

29.朱长才等,重点制造行业卫生防护距离标准制定,2015年度湖北省科技进步三等奖

30.宋世震等,职业接触苯的生物限值标准制定,2014年度湖北省科技进步二等奖

31.吴清明等,湖北省首届医学领军人才培养第三层次培养对象,湖北省首届医学领军人才培养工程,立项时间:2013

32.吴清明等,食管癌中P75NTR阳性细胞池的变化与放射抗拒机制的研究,湖北省新世纪高层次人才工程,立项时间:2012

  

  2近年取得代表性科研成果

1.  Zhenzhong Guo, et al.An Overview of An Artificial Nose System,Talanta.184(2018):93-102.

2.  Zhenzhong Guo, et al.Biosensors for Alzheimer's disease biomarkers detection: A review,Biochimie. 147(2018):13-24.

3.  Zhibing Zhang, et al.Intraflagellar transporterprotein 140 (IFT140), a component of IFT-A complex, is essential for male fertility and spermiogenesis in mice, Cytoskeleton. 75 (2018): 70-84.

4.  Hongxin Dong, et al.Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats.Psychoneuroendocrinology. 90(2018):92-101.

5.  Ruiwen Li, et al.A protective role of autophagy in TDCIPP-induced developmental neurotoxicity in zebrafish larvae,Aquat Toxicol.199(2018):46-54.

6.  Zhibing Zhang, et al.IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation, Biology of Reproduction. 96(2017): 993-1006.

7.  Ling Zhang, et al.Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5, Bmc Molecular Biology. 18 (2017): 2-2.

8.  Yuqin Shi,Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells, Environmental Toxicology. 32 (2017): 1055-1064.

9.  Hongxin Dong, et al.Pretreatment with Valproic Acid Diminishes Haloperidol-Induced Impairment in Memory and Motor Behavior through Modulation of Histone Acetylation,Nueropsychopharmacology.39(2017):1469-1478.

10.Jihua Ma, et al.Andrographolide inhibits arrhythmias and is cardioprotective in rabbits,Oncotarget. 8(2017):61226-61238.

11.Jihua Ma, et al.Icariin, a Novel Blocker of Sodium and Calcium Channels, Eliminates Early and Delayed Afterdepolarizations, As Well As Triggered Activity, in Rabbit Cardiomyocytes, Front Physiol. 29 (2017): 342.

12.Wenfang Li, et al.Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficts in aged rat,Food & Function. 8(2017):1323-1332.

13.Shuang Rong, et al.A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats, Nutrients. 9 (2017): 271.

14.Shuang Rong, et al.Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress,Food & Function. 8 (2017):4210-4216.

15.Qiong Yuan, et al.Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats,CellDeathAndDisease. 8(2017):e2624.

16.Zhenzhong Guo, et al.Molecularly imprinted polymer/metal organic framework based chemical sensors, Coatings. 6 (2016): 1-9.

17.Yuqin Shi, et al.Di-2-ethylhexyl phthalate induced oxidative damage involving FasL-associated apoptotic pathway in mouse spermatogenic GC-2spd cells, Molecular & Cellular Toxicology. 12 (2016): 381-389.

18.Yuqin Shi, et al.Di-(2-ethylhexyl) phthalate induces apoptosis of GC-2spd cells via TR4/Bcl-2 pathway, Environmental Toxicology and Pharmacology. 44 (2016): 18-24.

19.Zeng Yan, et al.TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease, Journal ofNeurochemistry. 136(2016): 620-636.

20.Yinghong Zhang, et al.Xanthine Oxidoreductase-An Important Functional Component of Differentiation, Apoptosis and Aggressiveness of Tumors Aggressiveness of Tumors,Cell Biology. 4 (2016): 24-30.

21.Qin Zhao, et al. Humic acids as both matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and adsorbent for magnetic solid phase extraction,Analytica Chimica Acta.889(2015):138-146.

22.Ting Zhou, et al.Switch regulation of interleukin-1 beta in downstream of inflammatory cytokines induced by two micro-sized silica particles on differentiated THP-1 macrophages, Environ Toxicol Pharmacol. 39 (2015): 457-466.

23.Lili Lu, et al.Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-κB signal cascade, Cancer Letter. 356 (2015): 470-478.

24.Zeng Yan, et al.7, 8-dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome,Neuropharmacology. 89(2015): 43-53.

25.Zeng Yan, et al.Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging, Journal ofNeuroscience. 31(2011):17800-17810.

 

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